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Title: The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope
Authors: Luzzati, Alma Luciana
Giacomini, Elena
Giordani, Luciana
Pugliese, Orsola
Viora, Marina
Chersi, Alberto
Issue Date: 1992
Publisher: Elsevier North Holland
Citation: Luzzati AL, Giacomini E, Giordani L, Pugliese O, Viora M, Chersi A. The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope. Immunology letters 1992;33:307-314.
ispartof: Immunology letters
Language: en
Type: Article
Peer reviewed: yes
Abstract: Da MEDLINE: Synthetic peptides containing amino acid sequence 218-238 of the core protein p24 of human immunodeficiency virus type 1 (HIV-1) and progressively shorter sequences at its C-terminus, were tested for their effect on antigen dependent in vitro responses of peripheral blood lymphocytes (PBL) from normal human donors. A peptide as short as 7 amino acids, corresponding to a highly conserved sequence, was able to inhibit in a dose-dependent manner the induction of a specific primary antibody response to the sheep red cell (SRC) antigen, as well as the proliferative response to recall microbial antigens. The results of this study constitute additional evidence of the immunoinhibitory effects of HIV components and may help to unravel some of the pathogenic mechanisms of AIDS. Moreover, they are of potential relevance for the development of immunoprophylactic and therapeutic strategies
ISSN: 0165-2478
Appears in Collections:6 - Pubblicazioni su serie non edite da ISS

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