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Title: Chronic infection in woodchucks infected by a cloned hepatitis delta virus
Authors: Ciccaglione, Anna Rita
Rapicetta, Maria
Fabiano, Antonia
Argentini, Claudio
Silvestro, Maria
Giuseppetti, Roberto
Varano, Franco
D'Urso, Nicoletta
Dinolfo, L.
Morgando, Anna
Bruni, Roberto
Ponzetto, Antonio
Issue Date: 1993
Publisher: Springer
Citation: Ciccaglione AR, Rapicetta M, Fabiano A, Argentini C, Silvestro M, Giuseppetti R, Varano F, D'Urso N, Dinolfo L, Morgando A, Bruni R, Ponzetto A. Chronic infection in woodchucks infected by a cloned hepatitis delta virus. Archives of virology - Supplementum 1993;8(Suppl.):15-21.
ispartof: Archives of virology - Supplementum
Language: en
Type: Article
Peer reviewed: yes
Abstract: Da MEDLINE: Two woodchucks (Marmota monax) intrahepatically inoculated with hepatitis delta virus (HDV) complementary DNA clones pSVL-D3 and pSVL-Ag showed virological and pathological signs of acute and chronic HDV infection. HDV-RNA and hepatitis delta antigen (HDAg) were detected in serum by slot-blot hybridization and by western blot five weeks after inoculation. Liver biopsy specimens collected at 8th week post inoculum were positive for HDV-RNA. Anti-HDV antibodies were detected at the 11th and 9th weeks, respectively. Histological finding of hepatocarcinoma and persistence of circulating HDV-RNA and anti-HDV were observed up to the 10th month. Both woodchucks produced "small" and "large" HDAg antigen, although the inoculated cloned DNA bears the coding capability solely for the small antigen. A transient decrease of woodchuck hepatitis virus DNA (WHV-DNA) level was observed during the peak of HDV infection. Successive inoculation of acute-phase serum in three woodchucks resulted in a successful infection in one of the animals
ISSN: 0939-1983
Appears in Collections:6 - Pubblicazioni su serie non edite da ISS

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