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Title: 3-aminobenzamide induces cytoskeleton rearrangement in M14 melanoma cells
Authors: Malorni, Walter
Rainaldi, Gabriella
Straface, Elisabetta
Rivabene, Roberto
Cossarizza, Andrea
Capri, Miriam
Monti, Daniela
Franceschi, Claudio
Issue Date: 1994
Publisher: Academic Press
Citation: Malorni V, Rainaldi G, Straface E, Rivabene R, Cossarizza A, Capri M, Monti D, Franceschi C. 3-aminobenzamide induces cytoskeleton rearrangement in M14 melanoma cells. Biochemical and biophysical research communications 1994;202(2):915-922.
ispartof: Biochemical and biophysical research communications
Language: en
Type: Article
Peer reviewed: yes
Abstract: Da MEDLINE: 3-aminobenzamide (3-ABA) is an inhibitor of poly-ADP-ribose-polymerase, an enzyme involved in numerous subcellular processes including cell death. With the aim of contributing to clarify the mode of action of the drug, which is still poorly understood, its effects on cultured melanoma cells M14 have been assessed. In particular, an impairment of cell growth accompanied by the formation of long and numerous dendritic-like protrusions has been detected. This finding appears to be due to a specific effect of the drug on some cytoskeletal elements and could be associated with its differentiating capability. This finding, together with previous data from our group--Biochem. Biophys. Res. Commun., (1994) 199, 525-530 and 1250-1255--suggests that cytoskeleton is an important target of 3-ABA
ISSN: 0006-291X
Appears in Collections:6 - Pubblicazioni su serie non edite da ISS

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