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Title: Both UVA and UVB induce cytoskeleton-dependent durface blebbing in epidermoid cells
Authors: Malorni, Walter
Donelli, Gianfranco
Straface, Elisabetta
Santini, Maria Teresa
Paradisi, Silvia
Giacomoni, Paolo Ulderico
Issue Date: 1994
Publisher: Elsevier Sequoia
Citation: Malorni V, Donelli G, Straface E, Santini MT, Paradisi S, Giacomoni PU. Both UVA and UVB induce cytoskeleton-dependent durface blebbing in epidermoid cells. Journal of photochemistry and photobiology B-Biology 1994;26:265-270.
ispartof: Journal of photochemistry and photobiology B-Biology
Language: en
Type: Article
Peer reviewed: yes
Abstract: Da MEDLINE: Data on the morphological changes induced by UVA or UVB irradiation of A431 epidermoid cells in culture are presented. After irradiation with different doses of UVB (120-2400 J m-2) or UVA (10(4)-10(5) J m-2), the membrane and cytoskeleton of these cells were analysed by immunofluorescence and scanning electron microscopy at different times after exposure (0-48 h). Both UVA and UVB alter microtubules and microfilaments and surface blebs are formed after UV irradiation. In particular, UVB induces multiple small blebs on the cells, while UVA induces one single large bleb on each cell. Since cytoskeletal damage and surface blebbing of this type are also induced by oxidative stress, these results add to the body of evidence indicating that UV radiation is capable of pro-oxidant behaviour. Specifically, the morphological changes described in this paper are reminiscent of the modifications which accompany epidermal keratinocytes during their transformation to sunburn cells after UV irradiation. The physiological implications of these findings are discussed
ISSN: 1011-1344
Appears in Collections:6 - Pubblicazioni su serie non edite da ISS

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