DSpace ISS DSpace ISS DSpace ISS

DSpace ISS >
01 - Istituto Superiore di Sanità >
6 - Pubblicazioni su serie non edite da ISS >

Title: Interferon gamma upregulates its own gene expression in mouse peritoneal macrophages
Authors: Di Marzio, Paola
Puddu, Patrizia
Conti, Lucia
Belardelli, Filippo
Gessani, Sandra
Issue Date: 1994
Publisher: Rockefeller University Press
Citation: Di Marzio P, Puddu P, Conti L, Belardelli F, Gessani S. Interferon gamma upregulates its own gene expression in mouse peritoneal macrophages. Journal of experimental medicine 1994;179(5):1731-1736.
ispartof: Journal of experimental medicine
Language: en
Type: Article
Peer reviewed: yes
Abstract: Da MEDLINE: Interferon gamma (IFN-gamma) exerts a variety of immunoregulatory effects on several cell targets. It is generally assumed that IFN-gamma is specifically produced by T and large granular lymphocytes. In this study, we show that IFN-gamma is constitutively expressed in resting mouse peritoneal macrophages (PM). Treatment of PM with cycloheximide results in a significant accumulation of IFN-gamma mRNA, suggesting that a short-lived IFN-gamma mRNA accumulates when protein synthesis is inhibited. Moreover, treatment of PM with IFN-gamma also results in a clear-cut accumulation of this mRNA. This effect is not observed in murine lymphocytes from mesenteric lymph nodes (which instead produce IFN-gamma after phytohemagglutinin treatment) and in mouse cell lines. The treatment of PM with IFN-gamma also results in secretion of IFN-gamma after 24-48 h. The upregulation of IFN-gamma expression is also found in PM from anti-asialo GM1-treated nude mice. We suggest that the ability of PM to produce this IFN-gamma is indicative of an autocrine mechanism. The macrophage IFN-gamma may play a role in the regulation of cell differentiation and immune response
ISSN: 0022-1007
Appears in Collections:6 - Pubblicazioni su serie non edite da ISS

Files in This Item:

There are no files associated with this item.

View Statistics
SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Valid XHTML 1.0! DSpace ISS  Istituto Superiore di Sanità  - Feedback