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Title: A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication
Authors: Coccia, Eliana Marina
Romeo, Giovanna
Nissim, Ahuva
Marziali, Giovanna
Albertini, Roberto
Affabris, Elisabetta
Battistini, Angela
Fiorucci, Gianna
Orsatti, Roberto
Rossi, Giovanni Battista
Chebath, Judith
Issue Date: 1990
Publisher: Academic Press
Citation: Coccia EM, Romeo G, Nissim A, Marziali G, Albertini R, Affabris E, Battistini A, Fiorucci G, Orsatti R, Rossi GB, Chebath J. A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication. Virology 1990;179(1):228-233.
ispartof: Virology
Language: en
Type: Article
Peer reviewed: yes
Abstract: Da MEDLINE: Treatment of cells with interferons (IFNs) induces resistance to virus infection. The 2'-5'oligo A (2-5A) synthetase/RNase L is one of the pathways leading to translation inhibition induced by IFN treatment. A murine cDNA encoding the 43-kDa 2-5A synthetase was cloned and sequenced. NIH-3T3 cell clones transfected with this cDNA expressed the enzymatic activity to various extents and exhibited resistance to encephalomyocarditis virus (EMCV) but not to vesicular stomatitis virus replication. The specific resistance to EMCV can be attributed to 2-5A synthetase
DOI: doi:10.1016/0042-6822(90)90292-Y
ISSN: 0042-6822
Appears in Collections:6 - Pubblicazioni su serie non edite da ISS

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