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Title: Alterations of lipid composition in Friend leukemia cell tumors in mice treated with tumor necrosis factor-alpha
Authors: Bravo, Elena
Carpinelli, Giulia
Proietti, Enrico
Belardelli, Filippo
Cantafora, Alfredo
Podo, Franca
Issue Date: 1990
Publisher: Elsevier Science Publishers
Citation: Bravo E, Carpinelli G, Proietti E, Belardelli F, Cantafora A, Podo F. Alterations of lipid composition in Friend leukemia cell tumors in mice treated with tumor necrosis factor-alpha. FEBS letters 1990;260(2):220-224.
ispartof: FEBS letters
Language: en
Type: Article
Peer reviewed: yes
Abstract: Da MEDLINE: Lipid analyses were carried out on transplantable murine Friend leukemia cell tumors, 6 h after intratumoral administration of tumor necrosis factor-alpha (TNF). The levels of the major phospholipid classes were uniformly decreased to about 70% of control values; free fatty acids were increased to about 170%; diacylglycerol was decreased to about 50% and triacylglycerol, the main lipid component, was not significantly altered. These results analysed in the light of concomitant alterations in the levels of phospholipid precursors and catabolites (determined in previous 31P NMR studies) and histological modifications demonstrated that at early stages of TNF-induced inhibition of tumor growth (a) phospholipid catabolism was significantly enhanced; (b) morphological changes were apparently correlated with alterations in the levels of phosphatidylcholine and its catabolic products
ISSN: 0014-5793
Appears in Collections:6 - Pubblicazioni su serie non edite da ISS

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