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Title: Antioxidant N-acetyl-cysteine increasing cell adhesion capability could facilitate the biocompatibility processes
Authors: Malorni, Walter
Matarrese, Paola
Rivabene, Roberto
Paradisi, Silvia
Donelli, Gianfranco
MeSH: Cell Adhesion; Antioxidants; Extracellular Matrix
Issue Date: 1996
Publisher: Butterworth-Heinemann In Association With The Biological Engineering Society
Citation: Malorni V, Matarrese P, Rivabene R, Paradisi S, Donelli G. Antioxidant N-acetyl-cysteine increasing cell adhesion capability could facilitate the biocompatibility processes. Biomaterials 1996;17(9):921-928.
ispartof: Biomaterials
Language: en
Type: Article
Peer reviewed: yes
Abstract: Da MEDLINE: Cell adhesion plays an important role in several cell processes and functions, including differentiation, proliferation and death. An important role for cell attachment to medical devices in biocompatibility studies has also been hypothesized. In this paper we report that the use of the antioxidant drug N-acetyl-cysteine is capable of increasing the adhesion properties of epithelial cells in culture. This is associated with a modification of specific cytoskeletal element assembly, such as microfilament system molecules. In contrast, no quantitative alterations in the expression of certain surface receptors for extracellular matrix molecules, such as VLA2, VLA3 and VLA6, are found. These data seem to indicate that intracellular oxidative balance, in particular of thiol groups, could play a key role in the cell adhesion properties and that N-acetyl-cysteine treatment, acting as 'thiol supply', could be of importance in several circumstances, including biocompatibility of medical devices
DOI: doi:10.1016/0142-9612(96)83288-1
ISSN: 0142-9612
Appears in Collections:6 - Pubblicazioni su serie non edite da ISS

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