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Title: Late acquisition of hyporesponsiveness to lipopolysaccharide by mycobacterium avium-infected human macrophages in producing tumor necrosis factor-alpha but not interleukin 1-beta and -6
Authors: Fattorini, Lanfranco
Xiao, Yan
Ausiello, Clara Maria
Urbani, Francesca
La Sala, Andrea
Mattei, Maurizio
Orefici, Graziella
Issue Date: 1996
Publisher: University of Chicago Press
Citation: Fattorini L, Xiao Y, Ausiello CM, Urbani F, La Sala A, Mattei M, Orefici G. Late acquisition of hyporesponsiveness to lipopolysaccharide by mycobacterium avium-infected human macrophages in producing tumor necrosis factor-alpha but not interleukin 1-beta and -6. Journal of infectious diseases 1996;173:1030-1034.
ispartof: Journal of infectious diseases
Language: en
Type: Article
Peer reviewed: yes
Abstract: Da MEDLINE: To investigate whether infection with Mycobacterium avium modifies the cytokine response of human macrophages (Mphi) to lipopolysaccharide (LPS), the release of interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha was determined in infected and uninfected Mphi, unstimulated or stimulated with LPS. In unstimulated Mphi, the release of IL-1 beta and IL-6 increased with the progress of infection while that of TNF-alpha progressively decreased. When Mphi were stimulated with LPS, IL-1 beta and IL-6 levels were always higher in infected than in uninfected cells, but levels of TNF-alpha significantly decreased in infected Mphi. A similar trend was obtained for TNF-alpha mRNA expression. Altogether, these results indicate that infected Mphi react to LPS stimulus with enhanced levels of IL-1 beta and IL-6 but are unable to restore the production of TNF-alpha impaired by the growth of the intracellular mycobacteria
ISSN: 0022-1899
Appears in Collections:6 - Pubblicazioni su serie non edite da ISS

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