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Title: Molecular mechanisms underlying the expression of the human HOX-5.1 gene
Authors: Cianetti, Luciano
Di Cristofaro, A.
Zappavigna, Vincenzo
Bottero, Lisabianca
Boccoli, Giovanni
Testa, Ugo
Russo, Giovanni
Boncinelli, Edoardo
Peschle, Cesare
Issue Date: 1990
Publisher: Oxford University Press
Citation: Cianetti L, Di Cristofaro A, Zappavigna V, Bottero L, Boccoli G, Testa U, Russo G, Boncinelli E, Peschle C. Molecular mechanisms underlying the expression of the human HOX-5.1 gene. Nucleic acids research 1990;18(15):4361-4368.
ispartof: Nucleic acids research
Language: en
Type: Article
Peer reviewed: yes
Abstract: Da MEDLINE: The complex mechanisms underlying homeobox genes expression involve regulation at transcriptional, post-transcriptional and translational levels. The multiple transcripts of the human HOX-5.1 gene are expressed differentially in tissue- and stage-specific patterns during embryogenesis, and differentially induced by retinoic acid (RA) in human embryonal carcinoma (EC) NT2/D1 cells. We have sequenced 6.3 Kb of the genomic region containing the HOX-5.1 gene and analyzed its mechanisms of expression. Two alternative promoters underlie the transcription of two classes of HOX-5.1-specific mRNAs. These classes differ in tissue and subcellular distribution, induction by RA, structure of the 5'-UT region and mRNA stability: these features are compatible with a differential function of the two classes of transcripts in embryogenesis
ISSN: 0305-1048
Appears in Collections:6 - Pubblicazioni su serie non edite da ISS

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