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Title: Clostridium difficile toxin B induces apoptosis in intestinal cultured cells
Authors: Fiorentini, Carla
Fabbri, Alessia
Falzano, Loredana
Fattorossi, Andrea
Matarrese, Paola
Rivabene, Roberto
Donelli, Gianfranco
Issue Date: 1998
Publisher: American Society for Microbiology
Citation: Fiorentini C, Fabbri A, Falzano L, Fattorossi A, Matarrese P, Rivabene R, Donelli G. Clostridium difficile toxin B induces apoptosis in intestinal cultured cells. Infection and immunity 1998;66(6):2660-2665.
ispartof: Infection and immunity
Language: en
Type: Article
Peer reviewed: yes
Abstract: Da MEDLINE: Toxigenic strains of the anaerobic bacterium Clostridium difficile produce at least two large, single-chain protein exotoxins involved in the pathogenesis of antibiotic-associated diarrhea and colitis. Toxin A (CdA) is a cytotoxic enterotoxin, while toxin B (CdB) is a more potent cytotoxin lacking enterotoxic activity. This study dealt with CdB, providing the first evidence that intestinal cells exposed to this toxin exhibit typical features of apoptosis in that a significant proportion of the treated cells displayed nuclear fragmentation and chromatin condensation. In keeping with ultrastructural data, CdB-treated cells showed the typical flow cytometric hallmark of apoptosis consisting of a distinct sub-G1 peak. The CdB-induced apoptotic response was dose and time dependent and not simply due to the actin-disrupting effect of the toxin or to the subsequent impairment of cell anchorage. Rather, the inhibition of proteins belonging to the Rho family due to CdB seems to play a role in the induction of apoptosis in intestinal cells. The origin of cells and the growth rate may also be cofactors relevant to such a response
ISSN: 0019-9567
Appears in Collections:6 - Pubblicazioni su serie non edite da ISS

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