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|Title: ||Chronic treatment with MIF-1 prevents the painful stimuli threshold elevation induced by neonatal handling in mice |
|Authors: ||D'Amore, Antonio|
|Issue Date: ||1991|
|Publisher: ||Elsevier Science|
|Citation: ||D'Amore A, Pieretti S, Chiarotti F, Loizzo A. Chronic treatment with MIF-1 prevents the painful stimuli threshold elevation induced by neonatal handling in mice. Peptides 1991;12(6):1291-1294. |
|Peer reviewed: ||yes|
|Abstract: ||Da MEDLINE: Chronic postnatal stressful handling results in a hyposensitivity to thermal nociceptive stimuli. This phenomenon is strongly affected by manipulations of the opioid system. In the present experiment, we report that chronic treatment with MIF-1 during the neonatal period prevents the behavioral alterations induced by handling while it is completely ineffective if injected acutely before antinociceptive testing by the tail flick test at 45 days of life |
|Appears in Collections:||6 - Pubblicazioni su serie non edite da ISS|
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