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Title: Protection against apoptosis by monoamine oxidase A inhibitors
Authors: Malorni, Walter
Giammarioli, Anna Maria
Matarrese, Paola
Pietrangeli, Paola
Agostinelli, Enzo
Ciaccio, Alessandra
Grassilli, Emanuela
Mondovì, Bruno
Issue Date: 1998
Publisher: Elsevier Science Publishers
Citation: Malorni V, Giammarioli AM, Matarrese P, Pietrangeli P, Agostinelli E, Ciaccio A, Grassilli E, Mondovì B. Protection against apoptosis by monoamine oxidase A inhibitors. FEBS letters 1998;426(1):155-159.
ispartof: FEBS letters
Language: en
Type: Article
Peer reviewed: yes
Abstract: Da MEDLINE: Several lines of evidence have been accumulating indicating that an important role may be played by mitochondrial homeostasis in the initiation phase, the first stage of apoptosis. This work describes the results obtained by using different inhibitors of monoamine oxidases (MAO), i.e. pargyline, clorgyline and deprenyl, on mitochondrial integrity and apoptosis. Both pargyline and clorgyline are capable of protecting cells from apoptosis induced by serum starvation while deprenyl is ineffective. These data represent the first demonstration that MAO-A inhibitors may protect cells from apoptosis through a mechanism involving the maintenance of mitochondrial homeostasis
ISSN: 0014-5793
Appears in Collections:6 - Pubblicazioni su serie non edite da ISS

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